c677t and a1298c mutations in the methylenetetrahydrofolate reductase gene in patients with recurrent abortion from the iranian azeri turkish
نویسندگان
چکیده
background: to assess whether the c677t and a1298c mutations in the methylenetetrahydrofolate reductase (mther) gene are associated with recurrent abortion (ra), we determined the frequencies of the t677 and c1298 mutations in patients and controls. materials and methods: mutations were determined by a rflp-pcr method in 53 patients and 61 matched controls. results: the frequencies of t alleles were 0.26 in patients and 0.29 in controls. the frequencies of c/c, t/c and t/t genotypes were 34 (55.7%), 22 (36.1%) and 5 (8.2%) in patients, and 27 (50.9%), 21 (39.6%) and 5 (9.43%) in controls. the c allele frequencies were 0.38 in patients and controls. c/c, a/c and a/a genotype distributions were 9 (14.8%), 28 (45.9%) and 24 (39.3%) in patients, and 8 (15.1%), 24 (45.3%) and 21 (39.6%) in controls. conclusion: there were no significant differences between patients and controls concerning the t677 and c1298 mutations.
منابع مشابه
C677T and A1298C Mutations in the Methylenetetrahydrofolate Reductase Gene in Patients with Recurrent Abortion from the Iranian Azeri Turkish
Background To assess whether the C677T and A1298C mutations in the methylenetetrahydrofolate reductase (MTHER) gene are associated with recurrent abortion (RA), we determined the frequencies of the T677 and C1298 mutations in patients and controls. MaterialsAndMethods Mutations were determined by a RFLP-PCR method in 53 patients and 61 matched controls. Results The frequencies of T alleles were...
متن کاملEvaluation of the Association between the C677T Polymorphism of Methylenetetrahydrofolate Reductase Gene and Recurrent Spontaneous Abortion
Introduction: One factor known to cause thrombophilia in women with unexplained recurrent spontaneous abortion (RSA) is C677T polymorphism of methylenetetrahydrofolate reductase gene. This study aimed to determine the association between RSA and MTHFR C677T polymorphism in Iranian patients. Methods: In this case-control study, 30 patients with previous history of two or more consecutive unexpla...
متن کاملAssociation between the A1298C Polymorphism of the Methylenetetrahydrofolate Reductase Gene and Recurrent Spontaneous Abortion
Introduction: A factor known to cause thrombophilia in women with recurrent pregnancy loss (RPL) is the A1298C polymorphism of methylenetetrahydrofolate reductase gene (MTHFR). This study aimed to determine the association between RPL and this polymorphism in Iranian patients. Methods: In this case-control study, 30 patients with a previous history of two or more consecutive unexplained abortio...
متن کاملMethylenetetrahydrofolate Reductase C677T and A1298C Polymorphism in Iranian Women With Idiopathic Recurrent Pregnancy Losses
BACKGROUND Recurrent pregnancy loss (RPL) is a serious problem for pregnancy. There is evidence that vascular complications play a principal role in RPL. Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in folate metabolism. Polymorphisms (C677T, A1298C) of MTHFR gene are associated with decreased MTHFR activity. OBJECTIVES The aim of this study was to determine the association bet...
متن کاملmethylenetetrahydrofolate reductase c677t and a1298c polymorphism in iranian women with idiopathic recurrent pregnancy losses
background recurrent pregnancy loss (rpl) is a serious problem for pregnancy. there is evidence that vascular complications play a principal role in rpl. methylenetetrahydrofolate reductase (mthfr) is a key enzyme in folate metabolism. polymorphisms (c677t, a1298c) of mthfr gene are associated with decreased mthfr activity. objectives the aim of this study was to determine the association betwe...
متن کاملevaluation of the association between the c677t polymorphism of methylenetetrahydrofolate reductase gene and recurrent spontaneous abortion
introduction: one factor known to cause thrombophilia in women with unexplained recurrent spontaneous abortion (rsa) is c677t polymorphism of methylenetetrahydrofolate reductase gene. this study aimed to determine the association between rsa and mthfr c677t polymorphism in iranian patients. methods: in this case-control study, 30 patients with previous history of two or more consecutive unexpla...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
international journal of fertility and sterilityجلد ۴، شماره ۳، صفحات ۱۳۴-۱۳۹
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023