c677t and a1298c mutations in the methylenetetrahydrofolate reductase gene in patients with recurrent abortion from the iranian azeri turkish

نویسندگان

morteza bagheri

isa abdi rad

mir davood omrani

fariba nanbakhsh

چکیده

background: to assess whether the c677t and a1298c mutations in the methylenetetrahydrofolate reductase (mther) gene are associated with recurrent abortion (ra), we determined the frequencies of the t677 and c1298 mutations in patients and controls. materials and methods: mutations were determined by a rflp-pcr method in 53 patients and 61 matched controls. results: the frequencies of t alleles were 0.26 in patients and 0.29 in controls. the frequencies of c/c, t/c and t/t genotypes were 34 (55.7%), 22 (36.1%) and 5 (8.2%) in patients, and 27 (50.9%), 21 (39.6%) and 5 (9.43%) in controls. the c allele frequencies were 0.38 in patients and controls. c/c, a/c and a/a genotype distributions were 9 (14.8%), 28 (45.9%) and 24 (39.3%) in patients, and 8 (15.1%), 24 (45.3%) and 21 (39.6%) in controls. conclusion: there were no significant differences between patients and controls concerning the t677 and c1298 mutations.

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منابع مشابه

C677T and A1298C Mutations in the Methylenetetrahydrofolate Reductase Gene in Patients with Recurrent Abortion from the Iranian Azeri Turkish

Background To assess whether the C677T and A1298C mutations in the methylenetetrahydrofolate reductase (MTHER) gene are associated with recurrent abortion (RA), we determined the frequencies of the T677 and C1298 mutations in patients and controls. MaterialsAndMethods Mutations were determined by a RFLP-PCR method in 53 patients and 61 matched controls. Results The frequencies of T alleles were...

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Methylenetetrahydrofolate Reductase C677T and A1298C Polymorphism in Iranian Women With Idiopathic Recurrent Pregnancy Losses

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methylenetetrahydrofolate reductase c677t and a1298c polymorphism in iranian women with idiopathic recurrent pregnancy losses

background recurrent pregnancy loss (rpl) is a serious problem for pregnancy. there is evidence that vascular complications play a principal role in rpl. methylenetetrahydrofolate reductase (mthfr) is a key enzyme in folate metabolism. polymorphisms (c677t, a1298c) of mthfr gene are associated with decreased mthfr activity. objectives the aim of this study was to determine the association betwe...

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evaluation of the association between the c677t polymorphism of methylenetetrahydrofolate reductase gene and recurrent spontaneous abortion

introduction: one factor known to cause thrombophilia in women with unexplained recurrent spontaneous abortion (rsa) is c677t polymorphism of methylenetetrahydrofolate reductase gene. this study aimed to determine the association between rsa and mthfr c677t polymorphism in iranian patients. methods: in this case-control study, 30 patients with previous history of two or more consecutive unexpla...

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عنوان ژورنال:
international journal of fertility and sterility

جلد ۴، شماره ۳، صفحات ۱۳۴-۱۳۹

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